Network-based drug repurposing for psychiatric disorders using single-cell genomics
Neuropsychiatric disorders lack effective treatments due to a limited understanding of underlying cellular and molecular mechanisms. To address this, we integrated population-scale single-cell genomics data and analyzed cell-type-level gene regulatory networks across schizophrenia, bipolar disorder, and autism (23 cell classes/subclasses). Our analysis revealed potential druggable transcription...
Personalized Single-cell Transcriptomics Reveals Molecular Diversity in Alzheimer’s Disease
Precision medicine for brain diseases faces many challenges, including understanding the heterogeneity of disease phenotypes. Such heterogeneity can be attributed to the variations in cellular and molecular mechanisms across individuals. However, personalized mechanisms remain elusive, especially at the single-cell level. To address this, the PsychAD project generated population-level single-nucleus...
Joint Variational Autoencoders for Multimodal Imputation and Embedding
Single-cell multimodal datasets have measured various characteristics of individual cells, enabling a deep understanding of cellular and molecular mechanisms. However, multimodal data generation remains costly and challenging, and missing modalities happen frequently. Recently, machine learning approaches have been developed for data imputation but typically require fully matched multimodalities...